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Insulin Resistance and Intracellular lipid accumulation

Totally asking from a place of very limited knowledge, but is insulin resistance and perhaps resulting Type 2 Diabetes actually symptomatic of and caused by intracellular lipid accumulation in the liver and the muscle? Some big "plant-based proponents" share this as the reason for Type 2, is it a valid assertion? If so, why does this same issue not come up in discussions related to Keto high-fat diets, or is it even an issue related to Keto diets? Technically do people who are using Keto to lose weight generally remain insulin resistant and is it just masked due to lack of carb intake? What are the mechanisms at work here? What is the most effective way to regain insulin sensitivity, what protocol would you support?

Mechanisms that Keeps Weight Stable

Most healthy individuals don’t eat precisely the number of calories they burn each day, often over eating a bit, yet weight stays stable. Apparently the body makes adjustments, even at a cellular level with ROS (?) metabolism. How does all that work, seems fascinating.

Semaglutide

1. What are your thought on Wegovy/Ozempic etc for patients who are not necessarily obese but just want to lose a "few pounds?" 2. Is it really a "game changer" for the obese as some people think? 3. What is it like for patients who get off of it with regards to their weight? 4. Does this medication only "work" because it reduces caloric intake or is there another mechanism at play in the brain? Thanks!!

Options to lower LDL? Statin data?

Even with a plant based (80%) whole foods diet with low saturated fat and rrgular exercise my cholesterol runs high. I dropped paleo after 5 years and have brought total cholesterol down 50 points to 210 and LDL to 140. No matter what I eat how or much I exercise that seems to be the limit. The data on statins does not look compelling and seems to only really have benefits for those who have already had a heart attack and can tolerate without side effects(interested in your opinion). What do you think and what about red yeast rice and plant sterols. I am 56 with low BMI and excellent diet and metabolic health and take no prescriptions so I am hesitant to. Thanks.

Glyphosate

Hi Danny! Glyphosate and GMO foods remain controversial and a source of ‘food fear’ for many. Can you speak to the latest evidence we have on the actual consumption levels of glyphosate in a typical diet and if there is cause for concern at typical intake levels? Thank you for all you do!