Corporate Health Recommendations
With growing health awareness it becomes increasingly important for companies to offer a work environment that pro-actively promotes health (at the very least does not harm it). This is especially crucial as demographics in most industrialized nations require companies to address topics like health to stay competetive for top young talent. If you were to advise a company to establish solid workplace health fundamentals, the 80/20 of it if you will, what would you tell them? What are the crucial elements to have in place? Thanks and keep up the good work, gents!
What is your assessment of the 2020 Hooper, et al review in Cochrane?
The systematic reviews done by Hooper, et al in Cochrane (in 2001, 2011, 2016 and then 2020) all report no association between modification or reduction of saturated fat intake with cardiovascular mortality, total mortality, non-fatal MI. The only significant effect reported was a relative risk reduction in combined cardiovascular events. Danny and Alan have frequently and strongly supported the idea that dietary replacement of saturated fat with PUFA and healthy carbs improves cardiovascular outcomes. But this Hooper study seems to consistently show that the only effect is on combined events. How should we - meaning non-experts - interpret these reviews, and can you point us to any other data that more strongly demonstrates a direct impact of saturated fat intake on cardiovascular risk outside of its impact on ApoB (the authors of the review specifically state increase in ApoB alone would not explain their findings for various outcomes). Thanks for all your great content. This podcast has changed my life.
Homocysteine
In the alternative health space it is quite popular to say that Homocysteine is causal for atherosclerosis while ApoB/LDL-P is not. There are some studies showing association with Homocysteine but also that reducing Homocysteine does not reduce risk (but were trials long enough or happened at too late a stage to make a statistically significant difference? ). Would be interested to find out more about the current science on this.