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Anorexia and morbid obesity and metabolic compensation

Can you talk about the conditions of anorexia and morbid obesity and how they essentially defy the rules of metabolic compensation? In other words- I understand anorexia to be a mental health condition where the individual starves themselves with a purpose to control weight. And morbid obesity being excessive consumption despite over fatness, etc. If the body has these numerous mechanisms by which calorie restriction or calorie over- consumption results in these compensatory processes-driving us to eat more/less slow us down/speed us up, and many more; do these individuals NOT "hear" these signals or are they just adept at ignoring them or is it that their bodies have lost the ability to compensate for their under or over consumption? Additionally, can anyone become anorexic or morbidly obese or is it merely genetics, and if you are in the proper life circumstance- you set these tendencies off? Thanks so much for your consideration of this convoluted question! Kristen in Dallas.

Stephen Guyenet vs. Gary Taubes

I just got through listening to the debate on Joe Rogan between these guys and firstly- clearly Guyenet "won," but I wanted to ask him about whey protein and why didn't he mention how whey protein increases insulin despite it being a protein and not a carbohydrate? If Taubes is all about insulin and carbs/sugars- wouldn't this fact destroy his hypothesis? Additionally I thought that overeating on any macronutrient would increase insulin simply because you are eating food? Also is it possible that both men are correct- that both schools of thought could co-exist and they both be playing a major role in obesity? I loved the debate but was thinking about these 2 things the whole time. Thanks!!

Fish consumption linked with cancer risk

What are your thoughts on the recently released study in the US ( NIH-AARP diet and health study ) linking 2 servings/week, or more. of fish to a 22% increase in risk of developing Skin Cancer. From what I read, the study didn't take into account some key confounders such as history of sun exposure or severe sun burns.

Obesity - Are the only efficacious interventions drugs and bariatric surgery?

It seems like there are significant differences in policies put forth between researchers from biomedical backgrounds and ones from public health policy backgrounds. Pr Allison touched on this during recent interviews, noting that there is very little evidence regarding the efficacy of upstream obesity prevention interventions, such community gardens, combatting food deserts, nutrition education, and cooking classes. On the other hand, governments are increasingly turning to such interventions, as well as policies such as front of pack labelling (Canada, 2022), nutrition facts tables, calorie labelling on menus, as well as the aforementioned ones. Given your research on determinants of health and obesity, what are some of the most promising interventions to prevent NCD morbidity, as well as stones unturned in public health policy? Would you agree with individuals such as Pr Allison that in our current environment, the only efficacious interventions are drugs and bariatric surgery? Regards, Gabriel

What's Up With Skinny People?

I'm a naturally skinny guy who helps other naturally skinny guys bulk up. I think it largely comes down to a blunted pleasure response to food, smaller stomachs, and/or higher NEAT. A lot of us seem to be taller and more thinly built, too. But why do you think things are things so different for us? Why is it so hard to gain weight? And what can we do about it?